Neisseria gonorrhoeae QC Overview

Neisseria gonorrhoeae is an aerobic, Gram-negative diplococcus in the family Neisseriaceae, and the causative agent of gonorrhoea, one of the most prevalent sexually transmitted infections worldwide. It infects the mucosal surfaces of the urogenital tract, rectum, pharynx, and conjunctivae, and untreated infections can lead to pelvic inflammatory disease, infertility, and disseminated gonococcal infection. The genome of N. gonorrhoeae (~2.2 Mb) is naturally competent for transformation and exhibits extensive antigenic variation in surface structures such as pili, Opa proteins, and lipooligosaccharides; the progressive acquisition of resistance to nearly every therapeutic antibiotic class has made multidrug-resistant gonorrhoea a critical global health threat.