Mannheimia haemolytica QC Overview

Mannheimia haemolytica is a Gram-negative, non-motile coccobacillus in the family Pasteurellaceae, and the primary bacterial agent of bovine respiratory disease (shipping fever), a major cause of economic loss in the cattle industry worldwide. It normally resides as a commensal in the upper respiratory tract of cattle but can invade the lungs following viral infection or stress. The genome of M. haemolytica (~2.7 Mb) encodes leukotoxin (LktA), a key RTX-family virulence factor, along with numerous iron acquisition and immune evasion genes, with significant serotype-associated genomic variation.